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FKK6

CAT: 0804-HY-168328-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168328-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FKK6 is a selective agonist for pregnane X receptor (PXR) with an EC50 of 1.2 µM. FKK6 exhibits good affinity with plasma proteins, and good metabolic metabolism in human microsomes. FKK6 inhibits PXR-related NF-κB signaling pathway, inhibits the expression of inflammatory factors, and exhibits anti-inflammatory activity against DSS -induced colitis in mouse model[1][2].
CAS Number
2238839-34-2
UNSPSC
12352005
Target
Interleukin Related; NF-κB
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fkk6.html
Purity
99.14
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C#CCC(O)(C1=CC=NC=C1)C2=CC3=CC=CC=C3N2S(=O)(C4=CC=CC=C4)=O
Molecular Formula
C23H18N2O3S
Molecular Weight
402.47
References & Citations
[1]Dvořák Z, et al., In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6. Bioorg Chem. 2024 Mar;144:107137.|[2]Dvořák Z, et al., Targeting the pregnane X receptor using microbial metabolite mimicry. EMBO Mol Med. 2020 Apr 7;12 (4) :e11621.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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