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DOG-1 Antibody

CAT: 0800-V3119IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V3119IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q5XXA6
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 904-986 from the human protein were used as the immunogen for this DOG-1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
DOG1.1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the DOG-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This DOG-1 antibody is available for research use only.
Storage Conditions
Store the DOG-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell Surface and Cytoplasm
Image Legend
IHC: Formalin-fixed, paraffin-embedded human GIST stained with DOG1 antibody (clone DOG1.1) .

UniProtKB · Q5XXA6

Anoctamin-1

ANO1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5XXA6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ANO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A2H4Y9B2, A8KAM3, E9PNA7, Q8IYY8, Q8N7V3
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumChlorideMetal-binding

Cellular component

Cell membraneCell projectionMembraneSynapse

Molecular function

Chloride channelDevelopmental proteinIon channel

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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