DOG-1 Antibody

CAT: 0013-GTR18573066Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18573066Size:7 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

UniProt

Q5XXA6

Reactivity

Human

Immunogen

Amino acids 904-986 from the human protein were used as the immunogen for this DOG-1 antibody.

Clonality

Monoclonal

Clone

DOG1.1

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The optimal dilution of the DOG-1 antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Mouse IgG1, kappa

UniProtKB · Q5XXA6

Anoctamin-1

ANO1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q5XXA6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ANO1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A0A2H4Y9B2, A8KAM3, E9PNA7, Q8IYY8, Q8N7V3

Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumChlorideMetal-binding

Cellular component

Cell membraneCell projectionMembraneSynapse

Molecular function

Chloride channelDevelopmental proteinIon channel

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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