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VCAM-1 Antibody

CAT: 0800-V2922SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2922SAF-100UGSize:100 µg
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Description
Recognizes a protein of 110kDa, identified as CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1), L1CAM and INCAM-100) . It is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. VCAM-1 serves as a ligand for leukocyte integrin (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P19320
Host
Mouse
Reactivity
Human
Immunogen
Stimulated human umbilical vein endothelial cells (HUVEC) were used as the immunogen for the VCAM-1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1.4C3
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the VCAM-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This VCAM-1 antibody is available for research use only.
Storage Conditions
Store the VCAM-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic, membrane
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human tonsil stained with VCAM-1 antibody (clone 1.4C3) .

UniProtKB · P19320

Vascular cell adhesion protein 1

VCAM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19320
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VCAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
V-CAM 1, VCAM-1
EC number
—
Processing
Precursor
Secondary accessions
A8K6R7, B4DKS4, E9PDD1, Q6NUP8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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