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CD71 Antibody / Transferrin Receptor

CAT: 0800-V2882SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2882SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a ~85-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This mAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P02786
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the CD71 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
TFRC/1149
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD71 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD71 antibody is available for research use only.
Storage Conditions
Store the CD71 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD71 antibody should be determined by the researcher.
Location
Cell surface

UniProtKB · P02786

Transferrin receptor protein 1

TFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02786
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFRC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TR, TfR, TfR1, Trfr
EC number
—
Processing
—
Secondary accessions
D3DXB0, Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variantMalaria

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Biological process

EndocytosisHost-virus interaction

Molecular function

Host cell receptor for virus entryReceptorTransducer

Domain

Signal-anchorTransmembraneTransmembrane helix

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