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Anti-MITF Antibody

CAT: 0800-V2713-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V2713-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, -B, -C, -H, and -M, which differ in the amino-terminal domain and in their expression patterns. The M isoform is restricted to the melanocyte cell lineage.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
O75030
Host
Mouse
Reactivity
Human
Immunogen
An N-terminus fragment of human MITF protein was used as the immunogen for the anti-MITF antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM290
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the anti-MITF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This anti-MITF antibody is available for research use only.
Storage Conditions
Store the anti-MITF antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC: Formalin-fixed, paraffin-embedded human melanoma stained with anti-MITF antibody (clone SPM290) .

UniProtKB · O75030

Microphthalmia-associated transcription factor

MITF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75030
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MITF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DJL2, D3K197, E9PFN0, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Disease

AlbinismDeafnessDisease variantMicrophthalmiaOsteopetrosisWaardenburg syndrome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmLysosomeMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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