Products for Research Use Only
RegisterLogin

Thyroglobulin Antibody

CAT: 0800-V2262IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V2262IHC-7MLSize:7 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites, detected at ~300kDa in western blot. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for thyroglobulin antibody even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently thyroglobulin antibody negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Thyroglobulin antibody, combined with calcitonin antibody, can identify medullary carcinomas of the thyroid. Furthermore, thyroglobulin antibody, combined with TTF1 antibody, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Human thyroid follicular cells were used as the immunogen for this Thyroglobulin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
2H11
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Thyroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Thyroglobulin antibody is available for research use only.
Storage Conditions
Store the Thyroglobulin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic and secreted
Image Legend
IHC staining of thyroid tissue with Thyroglobulin antibody (2H11) .
Product Datasheet
Loading...

Related Products

CatalogName
RQ4964TG Antibody / Thyroglobulin
V2883SAF-100UGTG Antibody / Thyroglobulin
V7001SAF-100UGTG Antibody / Thyroglobulin
V2883IHC-7MLTG Antibody / Thyroglobulin
V2883-20UGTG Antibody / Thyroglobulin
V2883-100UGTG Antibody / Thyroglobulin
V3628IHC-7MLRecombinant TG Antibody / Thyroglobulin
V3629-20UGRecombinant TG Antibody / Thyroglobulin
V8852-20UGTG Antibody Cocktail / Thyroglobulin
V3628-20UGRecombinant TG Antibody / Thyroglobulin

Alternative Products

CatalogName
GTR18175435Thyroglobulin Antibody

Popular Products