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TG Antibody / Thyroglobulin

CAT: 0800-RQ4964Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ4964Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:5000
UniProt
P01266
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Thyroglobulin / TG was used as the immunogen for the TG antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
AFEI-20
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the TG antibody at -20oC.
Limitations
This TG antibody is available for research use only.
Storage Conditions
Store the TG antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the TG antibody should be determined by the researcher.
Image Legend
Western blot testing with TG antibody. Predicted molecular weight ~305 kDa.

UniProtKB · P01266

Thyroglobulin

THYG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01266
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Tg
EC number
—
Processing
Precursor
Secondary accessions
O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Congenital hypothyroidismDisease variant

PTM

Disulfide bondGlycoproteinIodinationProteoglycanSulfation

Molecular function

HormoneThyroid hormone

Domain

RepeatSignal

Cellular component

Secreted

Biological process

Thyroid hormones biosynthesis

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