CD11b Antibody / MAC-1

• Description:

  CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

• Host:

  Rat

• Immunogen:

  B10 mouse spleen cells enriched for T lymphocytes were used as the immunogen for this CD11b antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Applications:

  FACS, IF, Functional studies

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This CD11b antibody is available for research use only.

• CAS Number:

  9007-83-4