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Clgn Antibody / Calmegin

CAT: 0800-RQ6851Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6851Size:100 µg
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Description
Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene. This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplasmic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P52194
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Recombinant mouse protein (amino acids N18-D611) was used as the immunogen for the Clgn antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Clgn antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Clgn antibody is available for research use only.
Storage Conditions
After reconstitution, the Clgn antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Clgn antibody should be determined by the researcher.
Location
Cytoplasmic (ER)
Image Legend
Western blot testing of 1) rat testis, 2) rat H9c2 (2-1) cells and 3) mouse testis tissue lysate with Clgn antibody. Predicted molecular weight ~70 kDa but can be observed at ~93 kDa with an ~101 kDa phosphorylated form.

UniProtKB · P52194

Calmegin

CLGN_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P52194
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Clgn
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q80YU3, Q9D2K5
Protein keywords

PTM

AcetylationDisulfide bondPhosphoprotein

Ligand

Calcium

Molecular function

ChaperoneDevelopmental protein

Biological process

DifferentiationMeiosisSpermatogenesis

Cellular component

Endoplasmic reticulumMembrane

Technical term

Reference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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