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Calnexin Antibody

CAT: 0800-V3796-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3796-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P27824
Host
Mouse
Reactivity
Human
Immunogen
A partial human recombinant protein was used as the immunogen for the Calnexin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CLNXN-1
Applications
IF/ICC, IHC-P, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Calnexin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Calnexin antibody is available for research use only.
Storage Conditions
Store the Calnexin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Calnexin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human renal cell carcinoma with Calnexin antibody (clone CLNXN-1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P27824

Calnexin

CALX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P27824
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CANX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R5V8, B4DGP8, B4E2T8, D3DWQ3, D6R9K3
Protein keywords

PTM

AcetylationDisulfide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

CalciumLectinMetal-binding

Molecular function

Chaperone

Technical term

Direct protein sequencingProteomics identificationReference proteome

Cellular component

Endoplasmic reticulumMembraneMitochondrion

Biological process

Host-virus interaction

Domain

RepeatSignalTransmembraneTransmembrane helix

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