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ZIC2 Antibody

CAT: 0800-RQ6448Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6448Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zinc finger protein ZIC2 is a protein that in humans is encoded by the ZIC2 gene. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
CAS Number
9007-83-4
UniProt
O95409
Host
Rabbit
Immunogen
Recombinant human protein (amino acids A31-Y214) was used as the immunogen for the ZIC2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS, Direct ELISA
Format
Purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the ZIC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ZIC2 antibody is available for research use only.

UniProtKB · O95409

Zinc finger protein ZIC 2

ZIC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95409
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZIC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5VYA9, Q9H309
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Cellular component

CytoplasmNucleus

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Disease

Disease variantHoloprosencephaly

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger

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