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ZIC3 Antibody

CAT: 0800-F54773-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54773-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1:50-1:100 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:50-1:100, Western blot: 1:500-1:1000
UniProt
O60481
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 239-267 from the human protein was used as the immunogen for the ZIC3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ZIC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ZIC3 antibody is available for research use only.
Storage Conditions
Aliquot the ZIC3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ZIC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human HL60 cell lysate with ZIC3 antibody. Predicted molecular weight ~51 kDa.

UniProtKB · O60481

Zinc finger protein ZIC 3

ZIC3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60481
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZIC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2CNW4, Q14DE5, Q5JY75
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Disease

Disease variantHeterotaxy

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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