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ZIC3 Antibody

CAT: 0800-RQ6449Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6449Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O60481
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human protein (amino acids N113-N455) was used as the immunogen for the ZIC3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the ZIC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ZIC3 antibody is available for research use only.
Storage Conditions
After reconstitution, the ZIC3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ZIC3 antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear
Image Legend
Flow cytometry testing of human MCF7 cells with ZIC3 antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= ZIC3 antibody.

UniProtKB · O60481

Zinc finger protein ZIC 3

ZIC3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60481
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZIC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2CNW4, Q14DE5, Q5JY75
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

Biological process

DifferentiationNeurogenesisTranscriptionTranscription regulation

Disease

Disease variantHeterotaxy

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

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