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Claudin 7 Antibody

CAT: 0800-RQ6250Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6250Size:100 µg
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Description
Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence (FFPE) : 5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O95471
Host
Rabbit
Reactivity
Human
Immunogen
A human recombinant partial protein (amino acids F92-V211) was used as the immunogen for the Claudin 7 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Claudin 7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Claudin 7 antibody is available for research use only.
Storage Conditions
After reconstitution, the Claudin 7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Claudin 7 antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human rectal cancer with Claudin 7 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH8 EDTA for 20 min.

UniProtKB · O95471

Claudin-7

CLD7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95471
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CLDN-7
EC number
—
Processing
—
Secondary accessions
B2R9X7, D3DTP0, Q6IPN3, Q7Z4Y7, Q9BVN0
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembraneTight junction

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix
Product Datasheet
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