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Lamin A/C Antibody

CAT: 0800-RQ4998Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ4998Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P02545
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human Lamin A/C / LMNA was used as the immunogen for the Lamin A/C antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
BEO-12
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the Lamin A/C antibody at -20oC.
Limitations
This Lamin A/C antibody is available for research use only.
Storage Conditions
Store the Lamin A/C antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the Lamin A/C antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human HeLa cell lysate with Lamin A/C antibody. Predicted molecular weight ~74 & 65 kDa.

UniProtKB · P02545

Prelamin-A/C

LMNA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02545
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LMNA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DI32, D3DVB0, D6RAQ3, E7EUI9, P02546, Q5I6Y4, Q5I6Y6, Q5TCJ2, Q5TCJ3, Q6UYC3, Q969I8, Q96JA2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondLipoproteinMethylationPhosphoproteinPrenylationUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyCharcot-Marie-Tooth diseaseCongenital muscular dystrophyDisease variantEmery-Dreifuss muscular dystrophyLimb-girdle muscular dystrophyNeurodegenerationNeuropathy

Domain

Coiled coil

Cellular component

Intermediate filamentNucleus

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