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Lamin B1 Antibody

CAT: 0800-F49714-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F49714-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Lamin B1 is one of the two B type proteins, B1.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P20700
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 459-488 from the human protein was used as the immunogen for this Lamin B1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Lamin B1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Lamin B1 antibody is available for research use only.
Storage Conditions
Aliquot the Lamin B1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Lamin B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat
Location
Nuclear membrane, nuclear
Image Legend
Western blot analysis of Lamin B1 antibody and Ramos lysate. Predicted molecular weight ~66kDa.

UniProtKB · P20700

Lamin-B1

LMNB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20700
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LMNB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R6J6, Q3SYN7, Q96EI6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinIsopeptide bondLipoproteinMethylationPhosphoproteinPrenylationUbl conjugation

Coding sequence diversity

Chromosomal rearrangement

Domain

Coiled coil

Disease

Disease variantIntellectual disabilityLeukodystrophyPrimary microcephaly

Cellular component

Intermediate filamentNucleus

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