BUB1B Recombinant Antibody / BubR1

BUB1B Recombinant Antibody / BubR1

• Description: 'Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt]
• CAS Number: 9000-83-3
• UniProt: O60566
• Host: Rabbit
• Immunogen: A synthetic peptide specific to human BUB1B was used as the immunogen for the BUB1B antibody.
• Clonality: Monoclonal
• Isotype: IgG
• Type: Recombinant
• Applications: WB
• Format: Purified
• Buffer: Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
• Reconstitution: Store the BUB1B antibody at -20oC.
• Limitations: This BUB1B antibody is available for research use only.