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BUB1B Antibody

CAT: 0800-RQ4759Size: 100 µLDry Ice: NoHazardous: No
CAT#:0800-RQ4759Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
'Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, ' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:5000
UniProt
O60566
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human BUB1B was used as the immunogen for the BUB1B antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
ABFG-2
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the BUB1B antibody at -20oC.
Limitations
This BUB1B antibody is available for research use only.
Storage Conditions
Store the BUB1B antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the BUB1B antibody should be determined by the researcher.
Image Legend
Western blot testing of human HepG2 lysate with BUB1B antibody. Predicted molecular weight ~120 kDa.

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