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IKK beta Antibody / IKBKB

CAT: 0800-RQ4716Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ4716Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. [UniProt]
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
O14920
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human IKK beta / IKBKB was used as the immunogen for the IKK beta antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
FOI-9
Type
Recombinant
Applications
WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the IKK beta antibody at -20oC.
Limitations
This IKK beta antibody is available for research use only.
Storage Conditions
Store the IKK beta antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the IKK beta antibody should be determined by the researcher.
Image Legend
Western blot testing of human Daudi cell lysate with IKK beta antibody. Predicted molecular weight ~87 kDa.

UniProtKB · O14920

Inhibitor of nuclear factor kappa-B kinase subunit beta

IKKB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14920
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IKBKB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB
EC number
2.7.11.10
Processing
—
Secondary accessions
B4DZ30, B4E0U4, O75327
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationHydroxylationIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variantSCID

Biological process

Host-virus interaction

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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