IKK beta Antibody

IKK beta Antibody

• Description: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
• UniProt: O14920
• Host: Mouse
• Immunogen: This IKK beta antibody was raised using purified His-tagged recombinant full length human IKKb.
• Clonality: Monoclonal
• Isotype: IgG1
• Applications: WB, ELISA
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the IKK beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This IKK beta antibody is available for research use only.