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Plasminogen Antibody / PLG

CAT: 0800-RQ4670Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4670Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg-560 and val-561, which is mediated by urokinase (PLAU) and tissue plasminogen activator (PLAT) . The main function of plasmin is to dissolve fibrin (see, e.g., FGA) clots. Plasmin, like trypsin, belongs to the family of serine proteinases. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P00747
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids EPLDDYVNTQGASLFSVTKKQL were used as the immunogen for the Plasminogen antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Plasminogen antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Storage Conditions
After reconstitution, the Plasminogen antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Plasminogen antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) placenta, 2) HL-60, 3) 22RV1, 4) 293T, 5) PANC-1, 6) SGC-7901, 7) Caco-2, 8) PC-3, 9) rat brain and 10) mouse brain lysate with Plasminogen antibody at 0.5ug/ml. Predicted molecular weight ~92 kDa, may be observed at higher molecular weights due to glycosylation.

UniProtKB · P00747

Plasminogen

PLMN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00747
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q15146, Q5TEH4, Q6PA00
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationFibrinolysisHemostasisTissue remodeling

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinZymogen

Disease

Disease variantThrombophilia

Molecular function

HydrolaseProteaseSerine protease

Domain

KringleRepeatSignal

Cellular component

Secreted

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