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PLGF Antibody

CAT: 0800-R30247Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R30247Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.
CAS Number
9007-83-4
UniProt
P49763
Host
Rabbit
Immunogen
An amino acid sequence from the C-terminus of human PLGF (REKMKPERCGDAVPRR) was used as the immunogen for this PLGF antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the PLGF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PLGF antibody is available for research use only.

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