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FLIP Antibody / c-FLIP

CAT: 0800-RQ4452Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4452Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CASP8 and FADD-like apoptosis regulator, also called c-FLIP (FLICE-like inhibitory protein), is a protein that in humans is encoded by the CFLAR gene. The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL (human recombinant protein)
UniProt
O15519
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Human FLIP recombinant protein (amino acids M1-D376) was used as the immunogen for the FLIP antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the FLIP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This FLIP antibody is available for research use only.
Storage Conditions
After reconstitution, the FLIP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the FLIP antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa, 2) placenta, 3) COLO-320, 4) PANC-1, 5) HepG2, 6) MDA-MB-231 and 7) mouse NIH3T3 lysate with FLIP antibody at 0.5ug/ml. Predicted molecular weight ~55 kDa (long form), observed here at ~43 kDa (p43c-FLIP) .

UniProtKB · O15519

CASP8 and FADD-like apoptosis regulator

CFLAR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15519
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CFLAR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interaction

Domain

Repeat

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