FLI1 Antibody

CAT: 0800-V7218-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V7218-20UGSize:20 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t (11;22) (q24; q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
FLVI1-1
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the FLI1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FLI1 antibody is available for research use only.
Storage Conditions
Store the FLI1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FLI1 antibody to be titered up or down for optimal performance.
Location
Nuclear
Image Legend
Western blot testing of 1) ThP1 and 2) Raji cell lysate with FLI1 antibody (clone FLVI1-1) . Predicted molecular weight ~50 kDa.
Product Datasheet
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