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RUNX1T1 Antibody

CAT: 0800-RQ4332Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4332Size:100 µg
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Description
Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene. This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Immunofluorescence/Immunocytochemistry: 2-4 µg/mL, Flow cytometry: 1-3ug/million cells, Immunoprecipitation: 2ug/500ug of lysate, Direct ELISA: 0.1-0.5 µg/mL (human recombinant protein)
UniProt
Q06455
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant human protein corresponding to amino acids T335-D510 was used as the immunogen for the RUNX1T1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF/ICC, FACS, IP, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the RUNX1T1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RUNX1T1 antibody is available for research use only.
Storage Conditions
After reconstitution, the RUNX1T1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the RUNX1T1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Western blot testing of 1) human placenta and 2) mouse testis lysate with RUNX1T1 antibody at 0.5ug/ml. Predicted molecular weight ~67 kDa.

UniProtKB · Q06455

Protein CBFA2T1

MTG8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q06455
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RUNX1T1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z4P4, E7EPN4, O14784, Q06456, Q14873, Q16239, Q16346, Q16347, Q6IBL1, Q6NXH1, Q7Z4J5, Q92479, Q9BRZ0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

DNA-bindingRepressor

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

Phosphoprotein

Disease

Proto-oncogene

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger
Product Datasheet
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