Runx1 Antibody

Runx1 Antibody

• Description: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B- dependent transcriptional activation (By similarity).
• CAS Number: 9007-83-4
• UniProt: Q03347
• Host: Rabbit
• Immunogen: This Runx1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 426-459 amino acids from the C-terminal region of mouse Runx1.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: WB, ELISA
• Format: Antigen affinity purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the Runx1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This Runx1 antibody is available for research use only.