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WWOX Antibody

CAT: 0800-RQ4282Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4282Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. It spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 1-2 µg/mL, FACS: 1-3ug/10^6 cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9NZC7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids M1-D245 was used as the immunogen for the WWOX antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the WWOX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This WWOX antibody is available for research use only.
Storage Conditions
After reconstitution, the WWOX antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the WWOX antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of 1) human MCF7, 2) rat brain, 3) rat kidney, 4) rat testis, 5) mouse brain, 6) mouse kidney and 7) mouse testis lysate with WWOX antibody at 0.5ug/ml. Predicted molecular weight ~46 kDa.

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