HP1 gamma Antibody / Heterochromatin protein-1 gamma / CBX3

HP1 gamma Antibody / Heterochromatin protein-1 gamma / CBX3

• Description: Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans. At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
• CAS Number: 9007-83-4
• UniProt: Q13185
• Host: Rabbit
• Immunogen: A recombinant human partial protein corresponding to amino acids A2-Q183 was used as the immunogen for the CBX3 antibody.
• Clonality: Polyclonal
• Isotype: IgG
• Applications: WB, IHC, IF, FACS, ELISA
• Format: Antigen affinity purified
• Buffer: 0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Reconstitution: After reconstitution, the CBX3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
• Limitations: This CBX3 antibody is available for research use only.