Gamma Catenin Antibody / Plakoglobin / JUP

• Description:

  Catenin gamma, also known as Junction plakoglobin (JUP) or Plakoglobin (PKGB), is a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. Catenin beta and gamma, vertebrate homologs of Drosophila armadillo, function in cell adhesion and the Wnt signaling pathway. Catenin gamma may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.

• Specifications:

  Western blot: 0.5-1 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells

• UniProt:

  P14923

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  An amino acid sequence from the N-terminus of human Gamma Catenin (LLATQVEGQATNLQRLAE) was used as the immunogen for this Gamma Catenin antibody.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB, IF, FACS

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

• Reconstitution:

  After reconstitution, the gamma Catenin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

• Limitations:

  This Gamma Catenin antibody is available for research use only.

• Storage Conditions:

  After reconstitution, the Gamma Catenin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

• Formulation:

  0.5 mg/mL if reconstituted with 0.2ml sterile DI water

• Applications Notes:

  The stated application concentrations are suggested starting amounts. Titration of the Gamma Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Location:

  Cell surface, cytoplasmic, cell junctions

• Image Legend:

  Immunofluorescent staining of FFPE human HeLa cells with Gamma Catenin antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.