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CFD Antibody / Complement Factor D

CAT: 0800-RQ4073Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4073Size:100 µg
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Description
Factor D is a protein which in humans is encoded by the CFD gene. The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by adipocytes into the bloodstream. And it stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P00746
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human partial protein corresponding to amino acids I26-A253 was used as the immunogen for the CFD antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CFD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CFD antibody is available for research use only.
Storage Conditions
After reconstitution, the CFD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CFD antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human breast cancer tissue with CFD antibody. Required HIER: steam section in pH8 EDTA buffer for 20 min and allow to cool prior to testing.

UniProtKB · P00746

Complement factor D

CFAD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00746
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CFD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.46
Processing
Precursor
Secondary accessions
B4DV76, Q5U5S1, Q86VJ5, Q8N4E0, Q8WZB4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Complement alternate pathwayImmunityInnate immunity

Disease

Disease variant

PTM

Disulfide bondZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal
Product Datasheet
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