Complement Factor B Antibody / CFB

CAT: 0800-R32391Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R32391Size:100 µg
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Description
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
Gene ID
629
UniProt
P00751
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids E518-L764 from the human protein were used as the immunogen for the Complement Factor B antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the Complement Factor B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Complement Factor B antibody is available for research use only.
Storage Conditions
After reconstitution, the Complement Factor B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Complement Factor B antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human 1) A549, 2) 293 and 3) HeLa cell lysate with Complement Factor B antibody. Expected/observed molecular weight ~86 kDa.
Product Datasheet
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