CD11c Antibody

• Description:

  CD11c, also known as Integrin, alpha X (ITGAX), is a genethat encodes for CD11c. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.

• Specifications:

  Western Blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Direct ELISA: 0.1-0.5 µg/mL

• UniProt:

  P20702

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A recombinant human partial protein corresponding to amino acids S161-T342 was used as the immunogen for the CD11c antibody.

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  WB, IHC-P, ELISA

• Purity:

  Antigen affinity purified

• Format:

  Antigen affinity purified

• Buffer:

  Lyophilized from 1X PBS with 2% Trehalose

• Reconstitution:

  After reconstitution, the CD11c antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

• Limitations:

  This CD11c antibody is available for research use only.

• Storage Conditions:

  After reconstitution, the CD11c antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

• Formulation:

  0.5 mg/mL if reconstituted with 0.2ml sterile DI water

• Applications Notes:

  Optimal dilution of the CD11c antibody should be determined by the researcher.

• CAS Number:

  9007-83-4

• Location:

  Membrane, cytoplasm

• Image Legend:

  Western blot testing of 1) mouse spleen and 2) mouse thymus tissue with CD11c antibody at 0.5ug/ml. Expected molecular weight: 128-150 kDa.