Histamine glutarimide

• Description:

  Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research[1].

• Product Name Alternative:

  XC8

• UNSPSC:

  12352005

• Target:

  CCR

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C1N (CCC2=CN=CN2) C (CCC1) =O

• Molecular Formula:

  C10H13N3O2

• Molecular Weight:

  207.23

• References & Citations:

  [1]Renner A, et al. Safety, pharmacokinetics and pharmacodynamics of a novel anti-asthmatic drug, XC8, in healthy probands. Pulm Pharmacol Ther. 2019 Dec;59:101852.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1464897-15-1