Histamine-d4

CAT: 0804-HY-B1204S1Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1204S1Size:1 Each
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Description
Histamine-d4 (Ergamine-d4) is deuterium labeled Histamine (HY-B1204) . Histamine is the agonist for histamine receptor and a vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7].
CAS Number
[751471-48-4]
Product Name Alternative
Ergamine-d4
UNSPSC
12352211
Target
Akt; Apoptosis; Endogenous Metabolite; Histamine Receptor; Isotope-Labeled Compounds; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Smiles
NC([2H])([2H])C([2H])([2H])C1=CN=CN1
Molecular Formula
C5H5D4N3
Molecular Weight
115.17
References & Citations
[1]Okabe S, et al. Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am J Dig Dis. 1977 Aug;22 (8) :677-84. |[2]Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. Health Psychol. 1997 Nov;16 (6) :547-53. |[3]Malmberg-Aiello P, et al., Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr;111 (4) :1269-79. |[4]Medina V, et al., Histamine-mediated signaling processes in human malignant mammary cells. Cancer Biol Ther. 2006 Nov;5 (11) :1462-71.|[5]Ferreira R, et al., Histamine modulates microglia function. J Neuroinflammation. 2012 May 8;9:90. |[6]MARTIN L. The effects of histamine on the vaginal epithelium of the mouse. J Endocrinol. 1962 Jan;23:329-40. |[7]Yang LP, et al. Spotlight on histamine dihydrochloride in acute myeloid leukaemia. Drugs Aging. 2011 Apr 1;28 (4) :325-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
sc-218580BHistamine-α, α, β, β-d4 Dihydrochloride
TRC-H436502-5MGHistamine-Alpha,Alpha,Beta,Beta-d4 Dihydrochloride
MBS6080943-01Histamine-a,a,b,b-d4 Dihydrochloride (1-H-Imidazole-4-ethanamine-d4, 5-Imidazole-ethylamine-d4, b-Aminoethylimidazole-d4, Maxamine-d4,)
H5080-10Histamine-a, a, b, b-d4 Dihydrochloride (1-H-Imidazole-4-ethanamine-d4, 5-Imidazole-ethylamine-d4, b-Aminoethylimidazole-d4, Maxamine-d4, _x000B_)
M14782-01Histamine

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