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MED13 Antibody

CAT: 0800-R32960Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32960Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene. This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL, Direct ELISA (recombinant human protein) : 0.1-0.5 µg/mL (BSA-free format available)
UniProt
Q9UHV7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A recombinant human protein corresponding to amino acids L61-Y240 was used as the immunogen for the MED13 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the MED13 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MED13 antibody is available for research use only.
Storage Conditions
After reconstitution, the MED13 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MED13 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) U-2 OS and 2) MCF7 cell lysate with MED13 antibody at 0.5ug/ml. Predicted molecular weight ~239-250 kDa, observed here at ~300 kDa.

UniProtKB · Q9UHV7

Mediator of RNA polymerase II transcription subunit 13

MED13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UHV7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MED13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RU05, O60334
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorRepressor

Disease

Disease variantIntellectual disability

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

Repeat

Biological process

TranscriptionTranscription regulation
Product Datasheet
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