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CCR1 Antibody

CAT: 0800-R32913Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32913Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1) . Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.
CAS Number
9007-83-4
Specifications
Western Blot: 0.5-1 µg/mL
UniProt
P51675
Host
Rabbit
Reactivity
Rat
Immunogen
A recombinant mouse protein corresponding to amino acids A168-T339 was used as the immunogen for the CCR1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the CCR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CCR1 antibody is available for research use only.
Storage Conditions
After reconstitution, the CCR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CCR1 antibody should be determined by the researcher.
Prediction Reactivity
Mouse
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of rat PC-12 cell lysate with CCR1 antibody at 0.5ug/ml. Predicted molecular weight 40-45 kDa.

UniProtKB · P51675

C-C chemokine receptor type 1

CCR1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P51675
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ccr1
Protein existence
2: Evidence at transcript level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
C-C CKR-1, CC-CKR-1, CCR-1, CCR1
EC number
—
Processing
—
Secondary accessions
Q6ZWR7, Q91VP9
Protein keywords

Cellular component

Cell membraneMembrane

PTM

Disulfide bond

Molecular function

G protein-coupled receptorReceptorTransducer

Technical term

Reference proteome

Domain

TransmembraneTransmembrane helix

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