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CCR10 Antibody

CAT: 0800-F43216-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F43216-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833) ; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P46092
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1-30 from the human protein was used as the immunogen for this CCR10 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CCR10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CCR10 antibody is available for research use only.
Storage Conditions
Aliquot the CCR10 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CCR10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
CCR10 antibody western blot analysis in HL-60 lysate. Predicted molecular weight ~38 kDa.

UniProtKB · P46092

C-C chemokine receptor type 10

CCR10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46092
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCR10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
C-C CKR-10, CC-CKR-10, CCR-10
EC number
—
Processing
—
Secondary accessions
Q4V749, Q6T7X2, Q9NZG2
Protein keywords

Cellular component

Cell membraneMembrane

PTM

Disulfide bond

Molecular function

G protein-coupled receptorReceptorTransducer

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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