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TAK1 Antibody / MAP3K7

CAT: 0800-R32443Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32443Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mitogen-activated protein kinase kinase kinase 7, also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3 µg/mL
UniProt
O43318
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids RLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQ were used as the immunogen for the TAK1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Prior to reconstitution, store at 4oC. After reconstitution, the TAK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This TAK1 antibody is available for research use only.
Storage Conditions
Prior to reconstitution, store at 4°C. After reconstitution, the TAK1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TAK1 antibody should be determined by the researcher.
Image Legend
Immunofluorescent staining of FFPE human SiHa cells with TAK1 antibody (green) and DAPI nuclear stain (blue) . HIER: steam section in pH6 citrate buffer for 20 min.

UniProtKB · O43318

Mitogen-activated protein kinase kinase kinase 7

M3K7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43318
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B2RE27, E1P523, O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3, Q9NZ70
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interactionStress responseTranscriptionTranscription regulation

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variant

Molecular function

KinaseSerine/threonine-protein kinaseTransferase
Product Datasheet
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