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SMURF1 Antibody

CAT: 0800-R32324Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32324Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. It is mapped to 7q22.1. This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
Q9HCE7
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Amino acids DHNNRTTQFTDPRLHHIMNHQCQLKE of human SMURF1 were used as the immunogen for the SMURF1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the SMURF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SMURF1 antibody is available for research use only.
Storage Conditions
After reconstitution, the SMURF1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SMURF1 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain and 2) MCF7 lysate with SMURF1 antibody. Expected/observed molecular weight ~86 kDa.

UniProtKB · Q9HCE7

E3 ubiquitin-protein ligase SMURF1

SMUF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HCE7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SMURF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hSMURF1
EC number
2.3.2.26
Processing
—
Secondary accessions
A4D279, B7ZMB6, B9EGV3, O75853, Q547Q3, Q9UJT8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmMembrane

Biological process

DifferentiationUbl conjugation pathway

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

Repeat

Molecular function

Transferase
Product Datasheet
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