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SMAD4 Antibody

CAT: 0800-R32216Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32216Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMAD4 (Mothers Against Decapentaplegic Drosophila Homolog of 4), also known as MADH4 or DPC4, is a protein that in humans is encoded by the SMAD4 gene. It belongs to the Darfwin family of proteins that modulate members of the TGFb protein superfamily. Hahn et al. (1996) identified the SMAD4 gene on chromosome 18q21.1. Howe et al. (1998) identified the SMAD4 gene within a region on 18q21.1 defined by linkage analysis in kindred with juvenile polyposis syndrome. To test directly the hypothesis that the SMAD4 gene is a tumor suppressor that is critical for transmitting signals from transforming growth factor-beta and related ligands. SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
Q13485
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids EIHLHRALQLLDEVLHTMPIADPQPLD of human SMAD4 were used as the immunogen for the SMAD4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the SMAD4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This SMAD4 antibody is available for research use only.
Storage Conditions
After reconstitution, the SMAD4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the SMAD4 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat brain, 2) mouse brain, 3) rat skeletal muscle, 4) mouse skeletal muscle, human 5) U87, 6) placenta, 7) HT1080, 8) HeLa and 9) NEURO lysate with SMAD4 antibody. Expected/observed molecular weight ~60 kDa.

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