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HSD11B2 Antibody / HSD11K

CAT: 0800-R32170Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32170Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Corticosteroid 11-β-dehydrogenase isozyme 2, also known as 11-β-hydroxysteroid dehydrogenase 2, is an enzyme that in humans is encoded by the HSD11B2 gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunohistochemistry (Frozen) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL
UniProt
P80365
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids EKRKQLLLANLPQELLQAYGKDYIEHLHGQFLH of human HSD11B2 were used as the immunogen for the HSD11B2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F, IF
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the HSD11B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HSD11B2 antibody is available for research use only.
Storage Conditions
After reconstitution, the HSD11B2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the HSD11B2 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of 1) rat kidney and 2) human placenta lysate with HSD11B2 antibody. Expected/observed molecular weight ~44 kDa.

UniProtKB · P80365

11-beta-hydroxysteroid dehydrogenase type 2

DHI2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P80365
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSD11B2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
11-DH2, 11-beta-HSD2
EC number
1.1.1.-
Processing
—
Secondary accessions
A7LB28, C5HTY7, Q13194, Q6P2G9, Q8N439, Q96QN8, Q99887, Q9UC50, Q9UC51, Q9UCW5, Q9UCW6, Q9UCW7, Q9UCW8
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variant

Cellular component

Endoplasmic reticulumMicrosome

Biological process

Lipid metabolismSteroid metabolism

Ligand

NAD

Molecular function

Oxidoreductase
Product Datasheet
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