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HSD17B2 Antibody

CAT: 0800-R30683Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30683Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSD17B2 (17-beta-hydroxysteroid dehydrogenase II), also called 17-beta-HSD II, is an enzyme with 387 amino acids, a predicted molecular weight of 42,782D, and associate with the membranes of the endoplasmic reticulum. The type 2 enzyme is capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And it activity distinguishing between disease-free and diseased endometria. It efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL
UniProt
P37059
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 373-387 (MPRALRMPNYKKKAT-human) were used as the immunogen for this HSD17B2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HSD17B2 antibody is available for research use only.
Storage Conditions
After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the HSD17B2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of HSD17B2 antibody and human placenta lysate; Predicted size: 43KD; Observed size: 43KD

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