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JNK2 Antibody (alpha/beta)

CAT: 0800-R32105Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R32105Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK2 is also known as MAPK9. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. Also, this gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL
UniProt
P45984
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids RNYVENRPKYPGIKFEELFPDWIFPSESERDK of human JNK2a/b were used as the immunogen for the JNK2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the JNK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This JNK2 antibody is available for research use only.
Storage Conditions
After reconstitution, the JNK2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the JNK2 antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HeLa and 2) COLO320 cell lysate with JNK2 antibody. Expected/observed molecular weight ~48 kDa.

UniProtKB · P45984

Mitogen-activated protein kinase 9

MK09_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P45984
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPK9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase 9, MAPK 9
EC number
2.7.11.24
Processing
—
Secondary accessions
A8K0S3, B5BU66, B5M0B4, D3DWQ8, D3DWQ9, Q15708, Q15710, Q15711, Q8N5C5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythms

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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STJ72746Anti-MAPK9 / JNK2 alpha (aa217-230) antibody
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MBS422699-01Goat anti-MAPK9/JNK2 beta (aa217-230) Antibody
dAP-2617Goat anti-MAPK9 / JNK2 alpha (aa217-230) Antibody
MBS422715-01Goat anti-MAPK9/JNK2 alpha (aa217-230) Antibody
APR08332GPolyclonal MAPK9 / JNK2 beta (aa217-230) Antibody (internal region)
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