Products for Research Use Only
RegisterLogin

OX40 Antibody / CD134

CAT: 0800-R32104Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R32104Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between the proteins plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, FACS: 1-3ug/10^6 cells
UniProt
P43489
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids AILLALYLLRRDQRLPPDAHKPP of human CD134/OX40 were used as the immunogen for the OX40 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the OX40 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This OX40 antibody is available for research use only.
Storage Conditions
After reconstitution, the OX40 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the OX40 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
Western blot testing of human 1) SW620 and 2) 22RV1 cell lysate with OX40 antibody. Expected molecular weight: 29-50 kDa depending on glcyosylation level.

UniProtKB · P43489

Tumor necrosis factor receptor superfamily member 4

TNR4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43489
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q13663, Q2M312, Q5T7M0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Molecular function

Host cell receptor for virus entryReceptor

Biological process

Host-virus interaction

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
V8349SAF-100UGCD134 Antibody / OX40
V8349-100UGCD134 Antibody / OX40
R31252Cd134 Antibody / Ox40
V8349-20UGCD134 Antibody / OX40
RQ4380Cd134 Antibody / Ox40
V8563-20UGOX40 Antibody
V8400-100UGOX40 Antibody
V8480SAF-100UGOX40 Antibody
V8563SAF-100UGOX40 Antibody
V8480-20UGOX40 Antibody

Alternative Products

CatalogName
ASA-B0348CD134/OX40 Antibody
MBS176222-01Anti-CD134/OX40 antibody
MBS2575467-01CD134/OX40 Polyclonal Antibody
GTR18574584OX40 Antibody / CD134 / TNFRSF4
GTR18678056-01Mouse OX40/CD134 Antibody
GTR18311721-01TNFRSF4/OX40/CD134 Antibody
MB9128CD134/OX40 monoclonal antibody
GTR18226180TNFRSF4/CD134/OX40 Antibody
MBS8564766-01CD134/OX40
C2515-20CD134 (OX40)

Popular Products