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RAB5 Antibody

CAT: 0800-R32002Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-R32002Size:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RAB5A (Ras-associated protein RAB5A), also called RAB5, is a protein that in humans is encoded by the RAB5A gene. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. The RAB5A gene is mapped on 3p24.3. RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling. It signals to the actin cytoskeleton through RNTRE, a RAB5-specific GTPase-activating protein (GAP) . RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes.
CAS Number
9007-83-4
Specifications
Western blot: 0.1-0.5 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P20339
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids KKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN of human RAB5A were used as the immunogen for the RAB5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the RAB5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RAB5 antibody is available for research use only.
Storage Conditions
After reconstitution, the RAB5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the RAB5 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of 1) rat brain, 2) mouse brain, and human 3) HeLa, 4) SW620, 5) 293 and 6) Jurkat lysate with RAB5 antibody. Expected/observed molecular weight ~25 kDa.

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