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MDM2 Antibody

CAT: 0800-R30449Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30449Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDM2 is an important negative regulator of the p53 tumor suppressor. The protein functions both as an E3 ubiquity lipase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation. Oliner et al. (1992) used MDM2 clones to localize the human gene to chromosome 12q13-q14 by analysis of human-hamster somatic cell hybrids.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q00987
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 343-358 (EKAKLENSTQAEEGFD) were used as the immunogen for this MDM2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MDM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MDM2 antibody is available for research use only.
Storage Conditions
After reconstitution, the MDM2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the MDM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MDM2 antibody and Lane 1: rat testis; 2: rat brain; 3: rat heart; 4: human SKOV-3; 5: COLO320; 6: HeLa; 7: mouse HEPA; 8: monkey COS7 cell lysate. Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.

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