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HYAL1 Antibody

CAT: 0800-R31302Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31302Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hyaluronidase-1, also known as LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL
UniProt
Q12794
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
An amino acid sequence from the N-terminus of human Hyaluronidase-1 (FTTVWNANTQWCLERH) was used as the immunogen for this HYAL1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the HYAL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HYAL1 antibody is available for research use only.
Storage Conditions
After reconstitution, the HYAL1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the HYAL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human HepG2, 2) human PC-3, 3) monkey COS-7, 4) rat liver, 5) mouse liver and 6) mouse kidney tissue lysate with HYAL1 antibody. Expected molecular weight: 48-60 kDa.

UniProtKB · Q12794

Hyaluronidase-1

HYAL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12794
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HYAL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Hyal-1
EC number
3.2.1.35
Processing
Precursor
Secondary accessions
Q6FH23, Q6PIZ6, Q7KYU2, Q7LE34, Q8NFK5, Q8NFK6, Q8NFK7, Q8NFK8, Q8NFK9, Q93013, Q9UKD5, Q9UNI8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantMucopolysaccharidosis

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainSignal

Molecular function

GlycosidaseHydrolase

Cellular component

LysosomeSecreted

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