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HYAL3 Antibody

CAT: 0800-R30955Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30955Size:100 µg
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Description
Hyaluronoglucosaminidase 3 is anenzyme that in humans is encoded by the HYAL3 gene, also known as LUCA3, Hyaluronidase-3, Lung carcinoma protein 3, LUCA-3, LUCA14, and Minna14. By Northern blot analysis, expression of a 2.1-kb transcript that was strongest in testis and bone marrow, but relatively weak in other organs. HYAL3 encodes a predicted 417-amino acid protein. This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
O43820
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
An amino acid sequence from the C-terminus of human Hyaluronoglucosaminidase 3 (SHQRCHGHGRCARRD) was used as the immunogen for this HYAL3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the HYAL3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This HYAL3 antibody is available for research use only.
Storage Conditions
After reconstitution, the HYAL3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the HYAL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of HYAL3 antibody and Lane 1: 22RV; 2: HeLa; 3: V20S cell lysate. Expected size: ~47KD

UniProtKB · O43820

Hyaluronidase-3

HYAL3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43820
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HYAL3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Hyal-3
EC number
3.2.1.35
Processing
Precursor
Secondary accessions
O60540, Q8NFK2, Q8NFK3, Q8NFK4, Q96E56, Q9BRW9
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmic vesicleEndoplasmic reticulumEndosomeMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainSignal

Biological process

Fertilization

Molecular function

GlycosidaseHydrolase

Technical term

Proteomics identificationReference proteome

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