HYAL2 Antibody

CAT: 0800-R30915Size: 100 µgDry Ice: NoHazardous: No

1 / 1

CAT#:0800-R30915Size:100 µg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Hyaluronoglucosaminidase 2, also known as hyaluronidase 2, and LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that the gene was expressed in all human tissues tested except adult brain, and Western blot analysis detected the protein in all mouse tissues examined except adult brain. HYAL2 is a glycosylphosphatidylinositol (GPI) -anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus (JSRV) . The findings of Rai et al. (2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

Q12891

Host

Rabbit

Reactivity

Human, Mouse, Rat.

Immunogen

Amino acids 142-157 (VRNWQDKDVYRRLSRQ-human) were used as the immunogen for this HYAL2 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal

Reconstitution

After reconstitution, the HYAL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This HYAL2 antibody is available for research use only.

Storage Conditions

After reconstitution, the HYAL2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

The stated application concentrations are suggested starting amounts. Titration of the HYAL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of HYAL2 antibody and Lane 1: HeLa; 2: SMMC-7721; 3: COLO320; 4: MCF-7; 5: HT1080 cell lysate

UniProtKB · Q12891

Hyaluronidase-2

HYAL2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q12891
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: HYAL2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Hyal-2
EC number: 3.2.1.35
Processing: Precursor
Secondary accessions: B3KRZ2, O15177, Q9BW29

Protein keywords

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Domain

EGF-like domainSignal

Molecular function

GlycosidaseHydrolaseReceptor

Technical term

Proteomics identificationReference proteome

Product Datasheet

Related Products

Catalog	Name
R31303	HYAL1 Antibody
R31302	HYAL1 Antibody
R30955	HYAL3 Antibody
RQ5819	Hyaluronidase 1 Antibody / HYAL1
RQ4624	NONO Antibody / p54nrb Antibody
F53954-0.05ML	Antibody
F53954-0.2ML	Antibody
F53952-0.2ML	Antibody
F53952-0.05ML	Antibody
V8674-20UG	Inhibin alpha Antibody / INHA antibody

Alternative Products

Catalog	Name
MBS8589889-01	HYAL2 Antibody